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Article

Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes.

Human molecular genetics - 1 Apr 2010

Kurbegovic Almira, Côté Olivier, Couillard Martin, Ward Christopher J, Harris Peter C, Trudel Marie

Abstract excerpt

While high levels of Pkd1 expression are detected in tissues of patients with autosomal dominant polycystic kidney disease (ADPKD), it is unclear whether enhanced expression could be a pathogenetic mechanism for this systemic disorder. Three transgenic mouse lines were generated from a Pkd1-BAC modified by introducing a silent tag via homologous recombination to target a sustained wild-type genomic Pkd1...

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Identifiers

PMID: 20053665
DOI: 10.1093/hmg/ddp588
PMCID: PMC4081642

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Source receipt: pubmed, retrieved 7 Sept 2026.

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