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The Role of the Co-Chaperone DNAJB11 in Polycystic Kidney Disease: Molecular Mechanisms and Cellular Origin of Cyst Formation

2024-03-04

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 and PKD2 , encoding polycystin-1 (PC1) and polycystin-2 (PC2), which are required for the regulation of the renal tubular diameter. Loss of polycystin function results in cyst formation. Atypical forms of ADPKD are caused by mutations in genes encoding endoplasmic reticulum (ER)-resident proteins through mechanisms that are not w...

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Literature Corpus work
11b43006-9ebb-56ad-b3b1-274f9b69e210
DOI
10.1101/2024.03.04.582938
Open publication

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