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Article

A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1.

Kidney international - 1 Jun 2008

Starremans P G, Li X, Finnerty P E, Guo L, Takakura A, Neilson E G, Zhou J

Abstract excerpt

Autosomal dominant polycystic kidney disease, a leading cause of end-stage renal disease in adults, is characterized by progressive focal cyst formation in the kidney. Embryonic lethality of Pkd1-targeted mice limits the use of these mice. Here we developed a floxed allele of Pkd1 exons 2-6. Glob...

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Source

Identifiers

PMID: 18385665
DOI: 10.1038/ki.2008.111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18385665-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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