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Article

Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.

The American journal of pathology - 1 Jan 2006

Jiang Si-Tse, Chiou Yuan-Yow, Wang Ellian, Lin Hsiu-Kuan, Lin Yuan-Ta, Chi Ying-Chih, Wang Chi-Kuang Leo, Tang Ming-Jer, Li Hung

Abstract excerpt

Mouse models for autosomal-dominant polycystic kidney disease (ADPKD), derived from homozygous targeted disruption of Pkd1 gene, generally die in utero or perinatally because of systemic defects. We introduced a loxP site and a loxP-flanked mc1-neo cassette into introns 30 and 34, respectively, of the Pkd1 locus to generate a conditional, targeted mutation. Significantly, before excision of the floxed exons and...

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Identifiers

PMID: 16400024
DOI: 10.2353/ajpath.2006.050342
PMCID: PMC1592650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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