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Article

Protein phosphatase 2A catalytic subunit α plays a MyD88-dependent, central role in the gene-specific regulation of endotoxin tolerance.

Cell reports - 28 Mar 2013

Xie Ling, Liu Cui, Wang Li, Gunawardena Harsha P, Yu Yanbao, Du Ruyun, Taxman Debra J, Dai Penggao, Yan Zhen, Yu Jing, Holly Stephen P, Parise Leslie V, Wan Yisong Y, Ting Jenny P, Chen Xian

Abstract excerpt

MyD88, the intracellular adaptor of most TLRs, mediates either proinflammatory or immunosuppressive signaling that contributes to chronic inflammation-associated diseases. Although gene-specific chromatin modifications regulate inflammation, the role of MyD88 signaling in establishing such epigenetic landscapes under different inflammatory states remains elusive. Using quantitative proteomics to enumerate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23434512
DOI: 10.1016/j.celrep.2013.01.029
PMCID: PMC4060247

Genes

TLR4

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