Article
Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.
PloS one - 1 Jan 2014
Opaluch Amanda M, Schneider Monika, Chiang Chih-yuan, Nguyen Quy T, Maestre Ana M, Mulder Lubbertus C F, Secundino Ismael, De Jesus Paul D, König Renate, Simon Viviana, Nizet Victor, MacLeod Graham, Varmuza Susannah, Fernandez-Sesma Ana, Chanda Sumit K
Abstract excerpt
Innate immune sensors such as Toll-like receptors (TLRs) differentially utilize adaptor proteins and additional molecular mediators to ensure robust and precise immune responses to pathogen challenge. Through a gain-of-function genetic screen, we identified the gamma catalytic subunit of protein phosphatase 1 (PP1-γ) as a positive regulator of MyD88-dependent proinflammatory innate immune activation. PP1-γ...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.