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Article

Protein Kinase D1: A New Component in TLR9 Signaling

1 Aug 2008

Abstract excerpt

Protein kinase D1 (PKD1) is expressed ubiquitously and regulates diverse cellular processes such as oxidative stress, gene expression, cell survival, and vesicle trafficking. However, the presence and function of PKD1 in monocytic cells are currently unknown. In this study, we provide evidence that PKD1 is involved in TLR9 signaling in macrophages. Class B-type CpG DNA (CpG-B DNA) induced activation of PKD1 via a...

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PMID: 18641342
DOI: 10.4049/jimmunol.181.3.2044

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