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Article

Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis

18 Sept 2024

Abstract excerpt

Activation of the Toll-like receptor 4 (TLR4) by bacterial endotoxins in macrophages plays a crucial role in the pathogenesis of sepsis. However, the mechanism underlying TLR4 activation in macrophages is still not fully understood. Here, we reveal that upon lipopolysaccharide (LPS) stimulation, lysine acetyltransferase CBP is recruited to the TLR4 signalosome complex leading to increased acetylation of the TIR...

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PMID: 39294473
DOI: 10.1038/s44318-024-00237-8

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