Article

PHLPP1 Counter-regulates STAT1-mediated Inflammatory Signaling

2019-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Inflammation is an essential aspect of innate immunity but also contributes to diverse human diseases. Although much is known about the kinases that control inflammatory signaling, less is known about the opposing phosphatases. Here we report that deletion of the gene encoding PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) protects mice from lethal lipopolysaccharide (LPS) challeng...

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Literature Corpus work: 7e9a37ee-4f89-5ced-9c9c-58ec5a444440
DOI: 10.1101/647883

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