Article

Setdb2 Regulates Inflammatory Trigger-Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms

2025-05-28

Abstract excerpt

<title>Abstract</title> <p>"Trained immunity" of innate immune cells occurs through a sequential two-step process where an initial pathogenic or sterile inflammatory trigger is followed by an amplified response to a later un-related secondary pathogen challenge. The memory effect is mediated at least in part through epigenetic modifications of the chromatin landscape. Here, we investigated the role of the epigene...

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Literature Corpus work: 47a8eb4c-de55-5196-a648-338174f8971f
DOI: 10.21203/rs.3.rs-6702384/v1

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