Article

Setdb2 Regulates Inflammatory Trigger-Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms

2025-03-19

Abstract excerpt

<h4>SUMMARY</h4> "Trained immunity" of innate immune cells occurs through a sequential two-step process where an initial pathogenic or sterile inflammatory trigger is followed by an amplified response to a later un-related secondary pathogen challenge. The memory effect is mediated at least in part through epigenetic modifications of the chromatin landscape. Here, we investigated the role of the epigenetic modifi...

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Literature Corpus work: c43e45e1-db6f-5b44-ab6e-1660d927735b
DOI: 10.1101/2025.03.18.644013

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