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Article

Tet2 restrains inflammatory gene expression in macrophages.

Experimental hematology - 1 Nov 2017

Cull Alyssa H, Snetsinger Brooke, Buckstein Rena, Wells Richard A, Rauh Michael J

Abstract excerpt

Tet methylcytosine dioxygenase 2 (TET2) is one of the earliest and most frequently mutated genes in clonal hematopoiesis of indeterminate potential (CHIP) and myeloid cancers, including myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). TET2 catalyzes the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, leading to DNA demethylation, and also affects transcription by recruiting...

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Source

Identifiers

PMID: 28826859
DOI: 10.1016/j.exphem.2017.08.001

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Tet2 restrains inflammatory gene expression in macrophages.PMID 28826859Read ↗

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