Article
Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2014
Gu Meidi, Ouyang Chuan, Lin Wenlong, Zhang Ting, Cao Xuetao, Xia Zongping, Wang Xiaojian
Abstract excerpt
The molecular mechanisms that fine tune TLRs responses need to be fully elucidated. Protein phosphatase-1 (PP1) has been shown to be important in cell death and differentiation. However, the roles of PP1 in TLR-triggered immune response remain unclear. In this study, we demonstrate that PP1 inhibits the activation of the MAPK and NF-κB pathway and the production of TNF-α, IL-6 in macrophages triggered by TLR3,...
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