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Article

MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex

1 Jan 2014

Abstract excerpt

Chronic inflammation underscores the pathogenesis of a range of human diseases. Lipopolysaccharide (LPS) elicits strong pro-inflammatory responses in macrophages through the transcription factor NF-κB. The epigenetic mechanism underlying LPS-induced pro-inflammatory transcription is not fully understood. Herein, we describe a role for myocardin-related transcription factor A (MRTF-A, also known as MKL1) in this...

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PMID: 25189621
DOI: 10.1242/jcs.152314

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