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Article

Coordinated Regulation of miR-155 and miR-146a Genes during Induction of Endotoxin Tolerance in Macrophages.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2015

Doxaki Christina, Kampranis Sotirios C, Eliopoulos Aristides G, Spilianakis Charalampos, Tsatsanis Christos

Abstract excerpt

Endotoxin tolerance occurs to protect the organism from hyperactivation of innate immune responses, primarily mediated by macrophages. Regulation of endotoxin tolerance occurs at multiple levels of cell responses and requires significant changes in gene expression. In the process of macrophage activation, induced expression of microRNA (miR)-155 and miR-146a contributes to the regulation of the inflammatory...

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Identifiers

PMID: 26538391
DOI: 10.4049/jimmunol.1500615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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