Article
Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism.
Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2013
François Paul, Voisinne Guillaume, Siggia Eric D, Altan-Bonnet Grégoire, Vergassola Massimo
Abstract excerpt
Early T-cell activation is selected by evolution to discriminate a few foreign peptides rapidly from a vast excess of self-peptides, and it is unclear in quantitative terms how this is possible. We show that a generic proofreading cascade supplemented by a single negative feedback mediated by the Src homology 2 domain phosphatase-1 (SHP-1) accounts quantitatively for early T-cell activation, including the effects...
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