Article
The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation.
Annual review of immunology - 1 Jan 1999
Germain R N, Stefanová I
Abstract excerpt
T cells constantly sample their environment using receptors (TCR) that possess both a germline-encoded low affinity for major histocompatibility complex (MHC) molecules and a highly diverse set of CDR3 regions contributing to a range of affinities for specific peptides bound to these MHC molecules. The decision of a T cell "to sense and to respond" with proliferation and effector activity rather than "to sense,...
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