Article

Differential Roles of Kinetic On- and Off-Rates in T-Cell Receptor Signal Integration Revealed with a Modified Fab’-DNA Ligand

2024-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Antibody-derived T-cell receptor (TCR) agonists are commonly used to activate T cells. While antibodies can trigger TCRs regardless of clonotype, they bypass native T cell signal integration mechanisms that rely on monovalent, membrane-associated, and relatively weakly-binding ligand in the context of cellular adhesion. Commonly used antibodies and their derivatives bind much more strongly than...

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Literature Corpus work: ac37acdd-52a6-5cc2-849d-45cd3fb05fdc
DOI: 10.1101/2024.04.01.587588

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