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Article

Control of T Cell Function by Positive and Negative Regulators

31 May 2002

Abstract excerpt

T cells are an essential element of the body's immune system. Engagement of the T cell receptor is responsible for initiating the signaling events that can activate, inactivate, or eliminate T cells, depending on the magnitude and duration of the signal. Control of T cell signaling occurs through both positive and negative regulation, as well as through the actions of molecular scaffolds that contribute to the...

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Identifiers

PMID: 12040176
DOI: 10.1126/science.1071551

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