Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength

16 Sept 2021

Abstract excerpt

How T cell receptor (TCR) signal strength modulates T cell function and to what extent this is modified by immune checkpoint blockade (ICB) are key questions in immunology. Using Nr4a3 -Tocky mice, we characterized early quantitative and qualitative changes that occur in CD4 + T cells in relation to TCR signaling strength. We captured how dose- and time-dependent programming of distinct co-inhibitory receptors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34534438
DOI: 10.1016/j.immuni.2021.08.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strengthPMID 34534438Read ↗

Antigen and Checkpoint Receptor Recalibration of T Cell Receptor Signal StrengthSemantic proximity Read ↗

High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor controlSemantic proximity Read ↗

Low-avidity T cells drive endogenous tumor immunity in mice and humansSemantic proximity Read ↗

A Conserved Landscape of Chemokine Receptor Co-expression Defines the Functional States of CD8+ T Cells in MelanomaSemantic proximity Read ↗

T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapiesSemantic proximity Read ↗

T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapiesSemantic proximity Read ↗

Exhausted T cell phenotypes depend on TCR signal strength.Semantic proximity Read ↗

OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrumSemantic proximity Read ↗

Precise engineering of chimeric antigen receptor expression levels defines T cell identity and functionSemantic proximity Read ↗

Signalome-wide mapping of the NFκB pathway in T-cells reveals novel targets for immunotherapySemantic proximity Read ↗

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptationSemantic proximity Read ↗

Temporal Mechanisms of T-Cell Fate Decisions under Immune Checkpoint Blockade Resolved by CanonicalTockySeqSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.