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Article

SYMPHONY, an information-theoretic method for gene-gene and gene-environment interaction analysis of disease syndromes.

Heredity - 1 Jun 2013

Knights J, Yang J, Chanda P, Zhang A, Ramanathan M

Abstract excerpt

We develop an information-theoretic method for gene-gene (GGI) and gene-environmental interactions (GEI) analysis of syndromes, defined as a phenotype vector comprising multiple quantitative traits (QTs). The K-way interaction information (KWII), an information-theoretic metric, was derived for multivariate normal distributed phenotype vectors. The utility of the method was challenged with three simulated data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23423149
DOI: 10.1038/hdy.2012.123
PMCID: PMC3656633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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