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Dimensionality reduction approach for many-objective epistasis analysis.

Briefings in bioinformatics - 19 Jan 2023

Yang Cheng-Hong, Hou Ming-Feng, Chuang Li-Yeh, Yang Cheng-San, Lin Yu-Da

Abstract excerpt

In epistasis analysis, single-nucleotide polymorphism-single-nucleotide polymorphism interactions (SSIs) among genes may, alongside other environmental factors, influence the risk of multifactorial diseases. To identify SSI between cases and controls (i.e. binary traits), the score for model quality is affected by different objective functions (i.e. measurements) because of potential disease model preferences and...

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Algorithms
Epistasis, Genetic
Models, Genetic
Multifactor Dimensionality Reduction
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 36458451
DOI: 10.1093/bib/bbac512

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