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Article

Reconstructability analysis as a tool for identifying gene-gene interactions in studies of human diseases.

Statistical applications in genetics and molecular biology - 1 Jan 2010

Shervais Stephen, Kramer Patricia L, Westaway Shawn K, Cox Nancy J, Zwick Martin

Abstract excerpt

There are a number of common human diseases for which the genetic component may include an epistatic interaction of multiple genes. Detecting these interactions with standard statistical tools is difficult because there may be an interaction effect, but minimal or no main effect. Reconstructability analysis (RA) uses Shannon's information theory to detect relationships between variables in categorical datasets....

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Identifiers

PMID: 20361857
DOI: 10.2202/1544-6115.1516
PMCID: PMC2861311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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