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Article

AMBIENCE: a novel approach and efficient algorithm for identifying informative genetic and environmental associations with complex phenotypes.

Genetics - 1 Oct 2008

Chanda Pritam, Sucheston Lara, Zhang Aidong, Brazeau Daniel, Freudenheim Jo L, Ambrosone Christine, Ramanathan Murali

Abstract excerpt

We developed a computationally efficient algorithm AMBIENCE, for identifying the informative variables involved in gene-gene (GGI) and gene-environment interactions (GEI) that are associated with disease phenotypes. The AMBIENCE algorithm uses a novel information theoretic metric called phenotype-associated information (PAI) to search for combinations of genetic variants and environmental variables associated...

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Identifiers

PMID: 18780753
DOI: 10.1534/genetics.108.088542
PMCID: PMC2567367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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