Article
Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseases.
Genetic epidemiology - 1 Nov 2011
Fan R, Zhong M, Wang S, Zhang Y, Andrew A, Karagas M, Chen H, Amos C I, Xiong M, Moore J H
Abstract excerpt
For complex diseases, the relationship between genotypes, environment factors, and phenotype is usually complex and nonlinear. Our understanding of the genetic architecture of diseases has considerably increased over the last years. However, both conceptually and methodologically, detecting gene-gene and gene-environment interactions remains a challenge, despite the existence of a number of efficient methods. One...
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