Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antipsychotic medications and cognitive functioning in bipolar disorder: moderating effects of COMT Val108/158 Met genotype.

BMC psychiatry - 19 Feb 2013

Arts Baer, Simons Claudia J P, Drukker Marjan, van Os Jim

Abstract excerpt

BACKGROUND: There is a negative association between the use of antipsychotics and cognitive functioning in bipolar patients, which may be mediated by altered dopamine signaling in selected brain areas, and moderation thereof by genetic sequence variation such as COMT Val108/158Met. The interaction between antipsychotic drug use and the COMT Val108/158Met genotype on two-year cognitive functioning in bipolar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Antipsychotic Agents
Share to Bipolar Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Cognition

Share to Genotype

Share to Neuropsychological Tests

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 23421957
DOI: 10.1186/1471-244X-13-63
PMCID: PMC3583705

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antipsychotic medications and cognitive functioning in bipolar disorder: moderating effects of COMT Val108/158 Met genotype.PMID 23421957Read ↗

COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophrenia.Semantic proximity Read ↗

Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder.Semantic proximity Read ↗

COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia.Semantic proximity Read ↗

The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder.Semantic proximity Read ↗

The impact of COMT polymorphisms on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovativ…Semantic proximity Read ↗

Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications.Semantic proximity Read ↗

Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

First- and second-generation antipsychotic medication and cognitive processing in schizophrenia.Semantic proximity Read ↗

MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.Semantic proximity Read ↗

Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia.Semantic proximity Read ↗

Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.