Article
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder.
Bipolar disorders - 1 Apr 2006
Dickerson Faith B, Boronow John J, Stallings Cassie, Origoni Andrea E, Cole Sara, Leister Flora, Krivogorsky Bogdana, Yolken Robert H
Abstract excerpt
BACKGROUND: Bipolar disorder is associated with deficits in cognitive functioning. The etiology of cognitive impairment in bipolar disorder may relate to both genetic and environmental factors. A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Val158Met polymorphism) has been identified as a risk factor for cognitive impairment in schizophrenia. Serological evidence...
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