Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder.

doi:10.1186/s40359-016-0118-3

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Article

Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder.

BMC psychology - 2 Apr 2016

Flowers Stephanie A, Ryan Kelly A, Lai Zongshan, McInnis Melvin G, Ellingrod Vicki L

Abstract excerpt

BACKGROUND: Second generation antipsychotics (SGAs) are increasingly utilized in Bipolar Disorder (BD) but are potentially associated with cognitive side effects. Also linked to cognitive deficits associated with SGA-treatment are catechol-O-methyltransferase (COMT) gene variants. In this study, we examine the relationship between cognition in SGA use and COMT rs5993883 in cohort sample of subjects with BD....

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Identifiers

PMID: 27039372
DOI: 10.1186/s40359-016-0118-3
PMCID: PMC4818866

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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