Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas.

doi:10.1007/s00401-013-1095-8

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Article

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas.

Acta neuropathologica - 1 May 2013

Fontebasso Adam M, Schwartzentruber Jeremy, Khuong-Quang Dong-Anh, Liu Xiao-Yang, Sturm Dominik, Korshunov Andrey, Jones David T W, Witt Hendrik, Kool Marcel, Albrecht Steffen, Fleming Adam, Hadjadj Djihad, Busche Stephan, Lepage Pierre, Montpetit Alexandre, Staffa Alfredo, Gerges Noha, Zakrzewska Magdalena, Zakrzewski Krzystof, Liberski Pawel P, Hauser Peter, Garami Miklos, Klekner Almos, Bognar Laszlo, Zadeh Gelareh, Faury Damien, Pfister Stefan M, Jabado Nada, Majewski Jacek

Abstract excerpt

Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade gliomas (over 30% of HGGs). To identify additional driver mutations in HGGs, we investigated a cohort of 60 pediatric HGGs using whole-exome sequencing (WES) and compared them to 543 exomes from non-cancer control samples. We identified mutations in SETD2, a H3K36 trimethyltransferase, in...

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Identifiers

PMID: 23417712
DOI: 10.1007/s00401-013-1095-8
PMCID: PMC3631313

Genes

SETD2
IDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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