Diffuse hemispheric glioma, H3 G34-mutant: Genomic landscape of a new tumor entity and prospects for targeted therapy

Abstract excerpt

“Diffuse hemispheric glioma, H3 G34-mutant” (DHG) is being included as a new CNS grade 4 tumor type in the forthcoming 5th edition of the WHO Classification of Tumors of the Central Nervous System. DHG arises within the cerebral hemispheres of teenagers and young adults and can histologically resemble anaplastic astrocytoma, glioblastoma, or CNS embryonal tumor.1 Affected patients have a somewhat more favorable...

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