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Article

A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4.

Acta neuropathologica - 1 Sept 2023

Williams Erik A, Brastianos Priscilla K, Wakimoto Hiroaki, Zolal Amir, Filbin Mariella G, Cahill Daniel P, Santagata Sandro, Juratli Tareq A

Abstract excerpt

Malignant brain tumors, known as H3K27-altered diffuse midline glioma (DMG) and H3G34-mutant diffuse hemispheric glioma (DHG), can affect individuals of all ages and are classified as CNS WHO grade 4. We comprehensively characterized 390 H3F3A-mutant diffuse gliomas (201 females, 189 males) arising in pediatric patients (under 20 years old) and adults (20 years and older) evaluated by the CGP program at...

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Brain Neoplasms
Child, Preschool
Genomics
Glioma
Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

World Health Organization

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Identifiers

PMID: 37524847
DOI: 10.1007/s00401-023-02609-6
PMCID: PMC10412483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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