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Article

Oncohistones and disrupted development in pediatric-type diffuse high-grade glioma.

Cancer metastasis reviews - 1 Jun 2023

Ocasio Jennifer K, Budd Kaitlin M, Roach Jordan T, Andrews Jared M, Baker Suzanne J

Abstract excerpt

Recurrent, clonal somatic mutations in histone H3 are molecular hallmarks that distinguish the genetic mechanisms underlying pediatric and adult high-grade glioma (HGG), define biological subgroups of diffuse glioma, and highlight connections between cancer, development, and epigenetics. These oncogenic mutations in histones, now termed "oncohistones", were discovered through genome-wide sequencing of pediatric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37119408
DOI: 10.1007/s10555-023-10105-2
PMCID: PMC10441521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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