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Article

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

Cancer discovery - 1 May 2013

Bjerke Lynn, Mackay Alan, Nandhabalan Meera, Burford Anna, Jury Alexa, Popov Sergey, Bax Dorine A, Carvalho Diana, Taylor Kathryn R, Vinci Maria, Bajrami Ilirjana, McGonnell Imelda M, Lord Christopher J, Reis Rui M, Hargrave Darren, Ashworth Alan, Workman Paul, Jones Chris

Abstract excerpt

UNLABELLED: Children and young adults with glioblastoma (GBM) have a median survival rate of only 12 to 15 months, and these GBMs are clinically and biologically distinct from histologically similar cancers in older adults. They are defined by highly specific mutations in the gene encoding the histone H3.3 variant H3F3A , occurring either at or close to key residues marked by methylation for regulation of...

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Source

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Identifiers

PMID: 23539269
DOI: 10.1158/2159-8290.CD-12-0426
PMCID: PMC3763966

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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