SETD2 mutations in primary central nervous system tumors

Abstract excerpt

Mutations in SETD2 are found in many tumors, including central nervous system (CNS) tumors. Previous work has shown these mutations occur specifically in high grade gliomas of the cerebral hemispheres in pediatric and young adult patients. We investigated SETD2 mutations in a cohort of approximately 640 CNS tumors via next generation sequencing; 23 mutations were detected across 19 primary CNS tumors. Mutations...

Topics

Join the communities discussing this publication.

• Chromatin Remodeling and Cancer
• Glioma Diagnosis and Treatment
• Protein Degradation and Inhibitors