Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expanding the spectrum of H3K27-altered gliomas: Hemispheric cases with midline epigenetic signatures.

Annals of diagnostic pathology - 1 Oct 2026

Mahajan Swati, Bhardwaj Supriya, Singh Jyotsna, Vasant Srinidhi, Mansoori Shabnam, Suri Ashish, Shah Shariq Ahmad, Garg Ajay, Sharma Mehar Chand, Suri Vaishali

Abstract excerpt

Diffuse midline glioma, H3 K27-altered (DMG-H3 K27), is an aggressive CNS tumor defined by midline location, loss of H3 p.K28me3 (K27me3), and characteristic molecular alterations. Rare hemispheric gliomas with H3 K27M mutations challenge this definition and are designated "diffuse hemispheric glioma with H3 K27M mutation, NEC" (DHG-H3 K27). Their biological and clinicopathological features remain poorly defined....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Exome Sequencing

Share to Glioma

Share to Histones

Share to Young Adult

Source

Identifiers

PMID: 42247824
DOI: 10.1016/j.anndiagpath.2026.152665

Genes

ATRX
BRAF
FGFR1
NF1
PDGFRA
PIK3CA
TERT
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expanding the spectrum of H3K27-altered gliomas: Hemispheric cases with midline epigenetic signatures.PMID 42247824Read ↗

Diffuse hemispheric glioma with H3 p.K28M (K27M) mutation: Unusual non-midline presentation of diffuse midline glioma, H3 K27M-altered?Semantic proximity Read ↗

Characteristics of H3K27M-mutant diffuse gliomas with a non-midline locationSemantic proximity Read ↗

Characteristics of H3K27M-mutant diffuse gliomas with a non-midline location.Semantic proximity Read ↗

Adult diffuse midline gliomas H3 K27-altered: review of a redefined entity.Semantic proximity Read ↗

The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant.Semantic proximity Read ↗

H3 K27M-mutant diffuse midline gliomas in different anatomical locations.Semantic proximity Read ↗

Clinico-pathological and molecular characterization of diffuse midline gliomas: is there a prognostic significance?Semantic proximity Read ↗

A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4.Semantic proximity Read ↗

Survival analysis of adult midline-located gliomas and diffuse midline gliomas: beyond the H3K27 mutation paradigm.Semantic proximity Read ↗

Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adultsSemantic proximity Read ↗

Challenge of Diagnostic Criteria for Diffuse Hemispheric Glioma (DHG), H3 G34-Mutant: A Case of DHG Without H3.3 Gene Alteration.Semantic proximity Read ↗

A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.