Article
Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers.
Cell reports - 21 Feb 2013
Chaumeil Julie, Micsinai Mariann, Ntziachristos Panagiotis, Deriano Ludovic, Wang Joy M-H, Ji Yanhong, Nora Elphege P, Rodesch Matthew J, Jeddeloh Jeffrey A, Aifantis Iannis, Kluger Yuval, Schatz David G, Skok Jane A
Abstract excerpt
V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspect of regulation is directed targeting of the RAG recombinase. Indeed, RAG accumulates at the 3' end of individual...
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