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Article

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

Nature immunology - 1 Jun 2009

Hewitt Susannah L, Yin Bu, Ji Yanhong, Chaumeil Julie, Marszalek Katarzyna, Tenthorey Jeannette, Salvagiotto Giorgia, Steinel Natalie, Ramsey Laura B, Ghysdael Jacques, Farrar Michael A, Sleckman Barry P, Schatz David G, Busslinger Meinrad, Bassing Craig H, Skok Jane A

Abstract excerpt

Coordinated recombination of homologous antigen receptor loci is thought to be important for allelic exclusion. Here we show that homologous immunoglobulin alleles pair in a stage-specific way that mirrors the recombination patterns of these loci. The frequency of homologous immunoglobulin pairin...

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Source

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Identifiers

PMID: 19448632
DOI: 10.1038/ni.1735
PMCID: PMC2693356

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19448632-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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