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Article

Role of recombination activating genes in the generation of antigen receptor diversity and beyond.

Immunology - 1 Dec 2012

Nishana Mayilaadumveettil, Raghavan Sathees C

Abstract excerpt

V(D)J recombination is the process by which antibody and T-cell receptor diversity is attained. During this process, antigen receptor gene segments are cleaved and rejoined by non-homologous DNA end joining for the generation of combinatorial diversity. The major players of the initial process of cleavage are the proteins known as RAG1 (recombination activating gene 1) and RAG2. In this review, we discuss the...

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Antibodies
DNA-Binding Proteins
RAG1 gene
RAG2 gene
Genes, RAG-1
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell

V(D)J Recombination

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Open in PubMed Open full text

Identifiers

PMID: 23039142
DOI: 10.1111/imm.12009
PMCID: PMC3530083

Genes

RAG1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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