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Article

DNA Synthesis Is Required for Reprogramming Mediated by Stem Cell Fusion

1 Feb 2013

Abstract excerpt

Embryonic stem cells (ESCs) can instruct the conversion of differentiated cells toward pluripotency following cell-to-cell fusion by a mechanism that is rapid but poorly understood. Here, we used centrifugal elutriation to enrich for mouse ESCs at sequential stages of the cell cycle and showed that ESCs in S/G2 phases have an enhanced capacity to dominantly reprogram lymphocytes and fibroblasts in heterokaryon...

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PMID: 23415233
DOI: 10.1016/j.cell.2013.01.012

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