Synergic reprogramming of mammalian cells by combined exposure to mitotic <i>Xenopus</i> egg extracts and transcription factors

Abstract excerpt

Transfer of somatic cell nuclei to enucleated eggs and ectopic expression of specific transcription factors are two different reprogramming strategies used to generate pluripotent cells from differentiated cells. However, these methods are poorly efficient, and other unknown factors might be required to increase their success rate. Here we show that Xenopus egg extracts at the metaphase stage (M phase) have a...

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