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Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells

7 Aug 2015

Abstract excerpt

Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) with transcription factors (e.g., Oct4 (O), Sox2 (S), Klf4 (K), and c-Myc (M)) greatly expands our understanding of cell fate control. iPSCs resemble embryonic stem cells (ESCs) but without immune rejection and ethic issues, and are therefore considered as a promising source for cell replacement therapy. Patient-derived iPSCs can...

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PMID: 26251165
DOI: 10.1038/cr.2015.96

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