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Article

Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells.

Science (New York, N.Y.) - 26 Aug 2005

Cowan Chad A, Atienza Jocelyn, Melton Douglas A, Eggan Kevin

Abstract excerpt

We have explored the use of embryonic stem cells as an alternative to oocytes for reprogramming human somatic nuclei. Human embryonic stem (hES) cells were fused with human fibroblasts, resulting in hybrid cells that maintain a stable tetraploid DNA content and have morphology, growth rate, and antigen expression patterns characteristic of hES cells. Differentiation of hybrid cells in vitro and in vivo yielded...

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Identifiers

PMID: 16123299
DOI: 10.1126/science.1116447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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