Nuclear reprogramming of somatic cells by embryonic stem cells is affected by cell cycle stage.

doi:10.1089/clo.2006.8.174

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Article

Nuclear reprogramming of somatic cells by embryonic stem cells is affected by cell cycle stage.

Cloning and stem cells - 1 Jan 2006

Sullivan Stephen, Pells Steve, Hooper Martin, Gallagher Ed, McWhir Jim

Abstract excerpt

Hybrid embryonic stem (ES)-like clones were generated by fusion of murine ES cells with somatic cells that carried a neo resistance gene under the transcriptional control of the Oct-4 promoter. The Oct-4 promoter was reactivated in hybrid ES cells formed by fusion with fetal fibroblasts, and all hybrid colonies were of ES rather than fibroblast phenotype, suggesting efficient reprogramming of fibroblast...

Topics

Alkaline Phosphatase
Animals
Base Sequence
Cell Cycle
Cell Differentiation
Cell Line
Cell Nucleus
Culture Media, Serum-Free
DNA Primers
DNA Replication
Gene Expression Regulation
Hybrid Cells
Mice
Phenotype
Pluripotent Stem Cells

Source

Open in PubMed

Identifiers

PMID: 17009894
DOI: 10.1089/clo.2006.8.174

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