Article
Finding common regions of alteration in copy number data.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Rueda Oscar M, Diaz-Uriarte Ramon, Caldas Carlos
Abstract excerpt
In this chapter, we review some recent methods designed for detecting recurrent copy number regions, that is, genomic regions that show evidence of being altered in a set of samples. We analyze Affymetrix SNP6 data from 87 Her2-type breast tumors from a recent study using three different methods, showing different definitions and features of common regions: studying heterogeneity in copy number profiles, refining...
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