Article
Computational methods for identification of recurrent copy number alteration patterns by array CGH.
Cytogenetic and genome research - 1 Jan 2008
Shah S P
Abstract excerpt
Recurrent DNA copy number alterations (CNA) are widely studied in diagnostic and cytogenetic cancer research. CNAs reveal locations that may alter gene dosage and thus expression of the genes contained within. Array comparative genomic hybridization has emerged as a popular high-throughput, genome-wide technique to interrogate tumor genomes for copy number alterations. When studying a group of tumors derived from...
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