Article
Global linkage map connects meiotic centromere function to chromosome size in budding yeast.
G3 (Bethesda, Md.) - 3 Oct 2013
Baryshnikova Anastasia, VanderSluis Benjamin, Costanzo Michael, Myers Chad L, Cha Rita S, Andrews Brenda, Boone Charles
Abstract excerpt
Synthetic genetic array (SGA) analysis automates yeast genetics, enabling high-throughput construction of ordered arrays of double mutants. Quantitative colony sizes derived from SGA analysis can be used to measure cellular fitness and score for genetic interactions, such as synthetic lethality. Here we show that SGA colony sizes also can be used to obtain global maps of meiotic recombination because...
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