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Article

A multi-omics analysis-based model to predict the prognosis of low-grade gliomas.

Scientific reports - 24 Apr 2024

Du Zhijie, Jiang Yuehui, Yang Yueling, Kang Xiaoyu, Yan Jing, Liu Baorui, Yang Mi

Abstract excerpt

Lower-grade gliomas (LGGs) exhibit highly variable clinical behaviors, while classic histology characteristics cannot accurately reflect the authentic biological behaviors, clinical outcomes, and prognosis of LGGs. In this study, we carried out analyses of whole exome sequencing, RNA sequencing and DNA methylation in primary vs. recurrent LGG samples, and also combined the multi-omics data to construct a...

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Brain Neoplasms
DNA Methylation
Exome Sequencing
Glioma
Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Grading

X-linked Nuclear Protein

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PMID: 38658591
DOI: 10.1038/s41598-024-58434-8
PMCID: PMC11043340

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