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Article

Molecular genetics of adult grade II gliomas: towards a comprehensive tumor classification system.

Journal of neuro-oncology - 1 Nov 2012

Figarella-Branger Dominique, Bouvier Corinne, de Paula André Maues, Mokhtari Karima, Colin Carole, Loundou Anderson, Chinot Olivier, Metellus Philippe

Abstract excerpt

Adult grade II low-grade gliomas (LGG) are classified according to the WHO as astrocytomas, oligodendrogliomas or mixed gliomas. TP53 mutations and 1p19q codeletion are the main molecular abnormalities recorded, respectively, in astrocytomas and oligodendrogliomas and in mixed gliomas. Although IDH mutations (IDH1 or IDH2) are recorded in up to 85 % of low-grade gliomas, IDH negative gliomas do occur. We have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22890969
DOI: 10.1007/s11060-012-0953-x

Genes

IDH1
INA
IDH2

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