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Article

A discontinuous SNAP-25 C-terminal coil supports exocytosis.

The Journal of biological chemistry - 27 Jul 2001

Chen Y A, Scales S J, Jagath J R, Scheller R H

Abstract excerpt

Membrane fusion requires the formation of four-helical bundles comprised of the SNARE proteins syntaxin, vesicle-associated membrane protein (VAMP), and the synaptosomal-associated protein of 25 kDa (SNAP-25). Botulinum neurotoxin E cleaves the C-terminal coil of SNAP-25, inhibiting exocytosis of norepinephrine from permeabilized PC12 cells. Addition of a 26-mer peptide comprising the C terminus of SNAP-25 that...

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Identifiers

PMID: 11373287
DOI: 10.1074/jbc.M103009200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A discontinuous SNAP-25 C-terminal coil supports exocytosis.PMID 11373287Read ↗

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