Article

Botulinum Neurotoxin A1 Signaling in Pain Modulation within Human Sensory Neurons

2025-06-24

Abstract excerpt

Botulinum neurotoxin type A1 (BoNT/A1) is an effective treatment for chronic migraine, but its direct mechanism of action on human sensory neurons has not been fully elucidated. While rodent studies on dorsal root ganglion (DRG) and trigeminal ganglion (TG) show that BoNT/A1 inhibits neurotransmission, including calcitonin gene-related peptide (CGRP) release, by cleaving SNAP-25, only one previous study has assess...

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Literature Corpus work: 5cb22839-6ed1-53c9-8924-399bac17d04b
DOI: 10.1101/2025.06.18.660472

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